2-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenyl 2-methylpropanoate fumarate

2-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenyl 2-methylpropanoate fumarate - Names and Identifiers

Name	Fesoterodine maleate
Synonyms	Toviaz SPM 907 SPM 8272 Spm 8272 Unii-eos72165S7 Fesoterodine maleate Fesoterodinefumarate Fesoterodine Fumarate Fesoterodine maleate (R)-Fesoterodine fumarate (R)-Fesoterodine Fumarate 2-((1R)-3-(Diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenyl isobutyrate 2-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenyl 2-methylpropanoate fumarate
CAS	286930-03-8
EINECS	639-689-3
InChI	InChI=1/C26H37NO3.C4H4O4/c1-18(2)26(29)30-25-13-12-21(17-28)16-24(25)23(22-10-8-7-9-11-22)14-15-27(19(3)4)20(5)6;5-3(6)1-2-4(7)8/h7-13,16,18-20,23,28H,14-15,17H2,1-6H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t23-;/m1./s1

2-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenyl 2-methylpropanoate fumarate - Physico-chemical Properties

Molecular Formula	C30H41NO7
Molar Mass	527.65
Melting Point	72-78°C
Solubility	DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
Appearance	Solid
Color	White to Off-White
Storage Condition	Inert atmosphere,2-8°C
Stability	Hygroscopic
In vitro study	Fesoterodine is rapidly and extensively converted to 5-HMT and therefore appears to be primarily responsible for the pharmacological activity of 5-HMT. In human M1-M5 cell lines, Fesoterodine is a competitive antagonist of cholinergic agonist-evoked responses and has similar potency and selectivity to radioligand studies. Fesoterodine caused a rightward shift of the concentration-effect curve of Carbachol in rat bladder muscle strips without decreasing its maximum and a concentration-dependent reduction of electric field stimulation (EFS)-induced contractions. Fesoterodin is hydrolyzed by non-specific esterases to 5-hydroxymethyl tolterodine (5-HMT), which is the active metabolite and is responsible for all antimuscarinic activity.

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